The most effective medications for autistic meltdowns and rages in children are risperidone and aripiprazole; in addition, they can ease common core symptoms, which in turn can improve sociability and reduce aggressive tendencies, self-injurious behaviors, and tantrums in autism.
These drugs address such behaviors usually around 30 to 50 percent of the time, but cannot address all behavior problems.
Another drug, Olanzapine is used for treating symptoms like aggression in children with autism. Fluoxetine(Prozac) and Sertraline(Zoloft) are FDA-approved for children age 7 and older to treat obsessive-compulsive disorder.
A breakthrough might be on the horizon. Roche, a Swiss pharmaceutical company, says it has gotten a designation from the FDA to help expedite what may be the first medication to treat core symptoms of ASD. The drug balovaptan has the potential to improve “core social interaction and communication” in those with autism. The results from a clinical trial in autistic adults suggest that balovaptan was effective in aiding to improve challenging social behaviors. It also was considered well tolerated and safe.